One minute ultraviolet exposure inhibits Toxoplasma gondii tachyzoite replication and cyst conversion without diminishing host humoral-mediated immune response
نویسندگان
چکیده
منابع مشابه
Immune response to Toxoplasma gondii.
Oral-route infection with Toxoplasma gondii sporozoites or tachyzoites leads to the rapid spread of quick-replicating cytolytic tachyzoites throughout the whole body. Toxoplasma easily crosses the blood-retina, encephalic and placental barriers. The acute phase of this infection lasts for less than around ten days. The parasite causes a very strong type-1 response focused on the interferon-gamm...
متن کاملSerological reactivity against cyst and tachyzoite antigens of Toxoplasma gondii determined by FAST-ELISA.
AIMS To obtain quantitative data on the human serological response to Toxoplasma gondii tachyzoite and bradyzoite antigens. METHODS Serum samples from 30 patients who had positive antibody titres against T gondii and from 14 who were seronegative, together with sequential serum samples from four infected individuals, were screened by FAST-ELISA. RESULTS Serum samples from the 30 seropositiv...
متن کاملCyst Formation from Virulent RH Strain of Toxoplasma gondii Tachyzoite: In Vitro Cultivation
BACKGROUND This study was performed to induce conversion of RH strain tachyzoites of Toxoplasma gondii to bradyzoites by pH changing of the culture medium. METHODS HeLa cell monolayers were infected at a 1:1 tachyzoite to cell ratio. Four hours after infection, the culture medium was removed and replaced with culture medium and 5% FCS, adjusted to pH 8 with NaOH. The culture was maintained at...
متن کاملShear Forces Enhance Toxoplasma gondii Tachyzoite Motility on Vascular Endothelium
Toxoplasma gondii is a highly successful parasite that infects approximately one-third of the human population and can cause fatal disease in immunocompromised individuals. Systemic parasite dissemination to organs such as the brain and eye is critical to pathogenesis. T. gondii can disseminate via the circulation, and both intracellular and extracellular modes of transport have been proposed. ...
متن کاملGarcinol Inhibits GCN5-Mediated Lysine Acetyltransferase Activity and Prevents Replication of the Parasite Toxoplasma gondii.
Lysine acetylation is a critical posttranslational modification that influences protein activity, stability, and binding properties. The acetylation of histone proteins in particular is a well-characterized feature of gene expression regulation. In the protozoan parasiteToxoplasma gondii, a number of lysine acetyltransferases (KATs) contribute to gene expression and are essential for parasite v...
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ژورنال
عنوان ژورنال: Experimental Parasitology
سال: 2014
ISSN: 0014-4894
DOI: 10.1016/j.exppara.2014.08.001